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Regulated CE Products

AMI Calx and Radiesse: What’s the Same, and What Isn’t

Is AMI Calx the same as Radiesse?” It’s a fair question. Both are calcium hydroxylapatite fillers, and one costs noticeably less. The short answer is that
they belong to the same class of product but are not the same product, and the difference matters for how you choose between them.

What they have in common

Both are injectable implants made of calcium hydroxylapatite (CaHA) microspheres suspended in a gel carrier, and both are supplied only to qualified practitioners.

Radiesse is made by Merz Aesthetics. Its instructions for use describe synthetic calcium hydroxylapatite in a carrier of sterile water, glycerin and sodium carboxymethylcellulose, with a stated particle size of 25–45 microns.

AMI Calx is part of the AMI range from Quiver Medic, a Korean company. It is described as CaHA microspheres in a carboxymethylcellulose gel.

So on paper, the core material is the same type.

Where they differ

AMI Calx vs Radiesse: A Buyer’s Comparison

The track record. Radiesse has US FDA approval for correcting moderate to severe facial wrinkles and folds, granted on 22/12/2006, and its instructions for use report the clinical studies behind that approval. There is a large body of published research on it. For AMI Calx, we found no published clinical studies under the product name at the time of writing. That doesn’t tell you anything about how it performs. It does mean the evidence behind the two products is not comparable, and you should weigh that yourself

“Same material” is not “same product”. Researchers who compared CaHA fillers from different manufacturers under an electron microscope found the particles differed in surface texture and shape, even where the chemistry and average size were similar. How a filler is manufactured is part of what it is, and two CaHA products are no more interchangeable by default than two hyaluronic acid fillers

Storage. Merz states controlled room temperature, 15–32°C, with a three-year expiry from manufacture for the 1.5ml syringe. Either way, check the expiry on the stock you’re sent, and store it where its stated range is actually met

What it costs per millilitre

ProductPackPrice Inc VATPrice Ex VATPer ML Ex VAT
AMI Calx1 x 1ml with 1 syringe£59.99£49.99£49.99
Radiesse1 x 1.5ml£138.00£115.00£76.67


Per millilitre, AMI Calx is about 35% lower than Radiesse at today’s prices. That is a real difference if you use CaHA regularly. But you’re comparing price, not equivalence, and the right volume per treatment is a clinical decision, not something a price table can tell you

The question we won’t answer

We’re not going to tell you which one gives better results, or that one can simply replace the other. That judgement belongs to the practitioner who holds clinical responsibility: it rests on the manufacturer’s instructions, your training, and the person in front of you. A supplier’s blog is the wrong place to make it

Before you switch: five questions

Is it UKCA or CE marked, and who is the manufacturer?

Ask for the certificate if it isn’t printed clearly on the pack.

Can I see the instructions for use for this exact presentation?

Any reputable supplier will provide them without argument.

Does my insurer cover it?

Some indemnity policies specify which products they cover. A two-minute call before you buy is better than finding out afterwards.

What is the expiry on the stock you’d send me?

Does my training cover it?

Technique for CaHA fillers is product-specific, and manufacturer training is the reference.

Both are in stock

Aesthetics Warehouse stocks Radiesse 1 × 1.5ml and AMI Calx 1ml, with current prices and stock on the product pages. If you’re choosing on supply grounds (price per ml, pack size, expiry), the numbers above are the ones to use. If you’re choosing on clinical grounds, speak to your trainer or the manufacturer first. For buying stock with a shorter expiry, see our guide to short-dated stock.

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